This happened in the recent past where some patients with a history of persistent vegetative state caused due to a brain trauma happened to recover from the condition when administered with generic Ambien (Zolpidem), or known better by its brand name Ambien. The drug was intended to treat insomnia or sleeplessness, were upon ingestion patients skip to sleep. Several cases of recovery from coma after accident upon Ambien usage have been reported around the world. One report from South Africa was regarded to the lamplight of this event.
Rian Bolton suffered a severe coma from a car crash and left motionless for about three years in the hospital bed. During the time doctor prescribed him Ambien in order to reduce internal sleep deprivation problem and it was then that to their surprise he managed to wake back to life and said “Hello Mommy’’. The event happened in the state of Kimberley in South Africa.
There were many other cases reported about Ambien usage in coma patients. Highly reputed medical researchers at an authentic online pharmacy led an extensive study regarding the use of Ambien in patients with brain trauma. They had done the Ambien study on 4 patients suffering from a persistent vegetative state where the reason for the brain trauma was different but all four shared same brain pattern during coma stage.
But significant brain activity was noted in all four patients upon administering Ambien as a sleep aid. They used an electroencephalography (EEG) on patients with and without Ambien in order to analyze its effects. This new study offered them with certain vital information to understand how the brain works during a medication and opened them a door to research much more effective and long-lasting alternative to the drug.
How does Ambien work on coma patients?
In a normal healthy person, the pill works by binding on to the GABA receptor, thereby altering the brain signals in order to induce sleep. A modified version of Ambien can even prolong the sleep hours or sleep quality using an extended release formula. Whereas in the case of patients suffering from a brain trauma followed by a coma the working of the brain shuts down and alters certain signaling in order to conserve energy.
The GABA is a depressant chemical that shuts almost all activities leading to a long-dormant state. During this time the brain receptors responding to GABA become hypersensitive and it is believed that during this time the receptor physical undergoes certain conformational changes leading to a reversal of activity. Thus, when Ambien binds to the receptor in order to induce sleepiness it enhances the brain signals promoting the wakefulness and breaks the dormant state of the patient.
As such, the strong relation between Ambien and brain trauma is yet to be studied and made applicable in the current medical science. A team of researchers is on the path of studying the effect on the patients reported with a positive result upon ingesting Ambien. It is believed that within next 5 years a successful development regarding the discovery might be born which soon will palliate the condition happened due to brain trauma.